Huntington's disease and dementia: from structural changes to clinical issues

Huntington's disease (HD) is an autosomal dominantneurodegenerative disorder, which occurs in patients witha mutation in the IT15 gene (huntingtin). Clinically, thedisease presents itself with not only motor symptoms butalso dementia. The aim of this study is to review andpresent all recent data, specifically those related to theneuropathology, biochemistry and diagnostic methods ofdementia in HD.