Investigating the Influence of 3D Cell Morphology on Neural Response During Electrical Stimulation

Neuronal compartment models are a basic and often used method to investigate the effect of electrical stim- ulation on the cell. As the outcome of the model heavily de- pends on the cells morphology and its position relative to the electrode, a realistic representation of the cell structure and its variations is of great importance. A method is pre- sented which allows the quick and easy creation of a three dimensional neuron morphology on the basis of a single two dimensional image. Basic properties of this morphology like local diameters, cell size or the amount of branching can easily be changed.