A fast heterogeneous algorithm for light fluence rate for prostate photodynamic therapy.
2010
To accurately calculate light fluence rate distribution in prostate photodynamic therapy (PDT), optical heterogeneity has
to be taken into account. Previous study has shown that a kernel based on analytic solution of the diffusion equation can
perform the calculation with accuracy comparable to Finite-element method. An assumption is made that light fluence
rate detected at a point in the medium is affected primarily by the optical properties of points (or elements) on the line
between the source and the point. The exponential decay term of the light fluence rate is expressed as an integral of
effective attenuation coefficient of each point along the line. The kernel method is first developed for a point source and
then extended for a linear source. A linear source is considered being composed of multiple point sources and light
fluence rate is summation of the fluence rates generated by the point sources. In this study, we have implemented a fast
ray-trace algorithm to substantially speed up the calculation. The kernel calculation is compared with FEM calculation
and is examined with light fluence rate measurements. The examination with clinical measurement data shows that
calculated fluence rates present similar features in distribution as the measurement, with errors of 30%-70% for the peak
fluence rates. We concluded that our heterogeneous algorithm is potentially valuable for light fluence rate optimization
during interstitial PDT.
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