Gastric emptying and small and large bowel transit of non-disintegrating tablets in fasted subjects

Abstract The gastrointestinal transit of non-disintegrating tablets was investigated in fasted subjects. The tablets (5 × 5 mm diameter) were administered on 3 consecutive days. Transit of the tablets was monitored using γ-scintigraphy. The tablets emptied from the stomach and traversed the small intestine as a bolus. The rate of transit through the colon showed a large inter-subject variation. However, in all cases, the tablets dispersed throughout the colon.