IMPROVEMENT IN DIASTOLIC INDICES BY RANOLAZINE: A POTENTIAL MECHANISM FOR ITS ANTI-ISCHEMIC AND ANTIARRHYTHMIC EFFECTS

Ranolazine (R) is approved for the management of chronic angina. While the exact mechanism of action of R is unknown, it has been found to affect the cardiac late sodium current, as well as inhibit the rapid delayed rectifier potassium current, which is effective in patients with ventricular and