PP096-SUN: Inverse Relationship Between Carotenoids and Estradiol Levels in Older Women: Implication for Estrogen-Dependent Cancers?

Rationale: The HSCT patients have a tendency to lower serum vitamin D (VD). There is an important role in the regulation of VD and lymphocyte function T. The VD has an immunomodulatory effect that correlates with an increased incidence of Chronic GVHD and may increase mortality in this group of patients. Additionally, serum vitamin D levels are related to bacterial infection, ICU and relapse after HSCT. Objective: Analyse the relationship between disability and serum levels of vitamin D and risk of developing Acute GVHD. Methods: Retrospective study in Oncology and Hematology Department of the Albert Einstein Hospital (HIAE), with 19 patients (10 women, 9 men), adults (>18 years) who underwent HSCT, 42% of allogeneic related, 37% of unrelated allogeneic and 21% haploidential. The mean age was 46 years (±16) and weight 67 kg (±17). Of these patients, 59% had normal body mass index (BMI) (kg/m2), 21% overweight, 5% obese and 16% malnutrition. The exam for measurement of serum vitamin D (25-hydroxyvitamin D) was requested at the time of admission of the patient before the start of HSCT. The results of serum VD were classified into 50 nmol/ml normal. Results: There was a significant and negative correlation between BMI and serum levels of VD (rp = 0.5). 53% of patients had GVHD, but there was no significant relationship of the same with the other variables. There was a trend GVHD in the presence of low serum vitamin D also present in 53% of cases. Conclusion: GVHD is a disease with a high risk for patients undergoing HSCT, having great impact on the quality of life. Overweight and obese patients who have lower levels of VD should be better monitored, as tending to a higher risk of developing this complication.