Synthetic method of bedaquiline impurity
2017
The invention discloses a synthetic method of bedaquiline impurity. Bedaquiline which is used as a raw material undergoes catalytic hydrogenation with palladium-charcoal under the alkaline condition for debromination. The yield reaches 90%. In comparison with a published method, the method of the invention is simpler and more feasible, and yield is also greatly increased.
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