Synthesis of New Substituted Quinolizidines as Potential Inhibitors of Ergosterol Biosynthesis.

Abstract Carbocationic species (High Energy Intermediates) have been postulated as intermediates in the course of enzymatic synthesis of ergosterol. Protonated aza-analogues of the sterol are thus potential inhibitors. The synthesis of substituted quinolizidines ( 3 ) is reported. 4-Methoxy-2,3-dimethylpyridine ( 4 ) was metalated and reacted with substituted 3-chloropropanal to build the 1-methyl-2-quinolizidinone. The lateral chain was prepared via a Wittig-Horner reaction.