Serotonin-promoted elevation of ROS levels may lead to cardiac pathologies in diabetic rat
2015
Patients with diabetes mellitus (DM) develop tendencies toward heart disease.
Hyperglycemia induces the release of serotonin from enterochromaffin cells
(EC). Serotonin was observed to elevate reactive oxygen species (ROS) and
downregulate antioxidant enzymes. As a result, elevated levels of serotonin
could contribute to diabetic complications, including cardiac hypertrophy. In
the present study, diabetes mellitus was induced in rats by alloxan
administration; this was followed by the administration of serotonin to
experimental animals. ROS, catalase (CAT), superoxide dismutase (SOD), B-type
natriuretic peptide (BNP) expression, and histopathological assessments were
performed. Elevated ROS concentrations and decreased antioxidant enzyme
activities were detected. Further, we observed an increase in cell surface
area and elevated BNP expression which suggests that events associated with
cardiac hypertrophy were increased in serotonin-administered diabetic rats.
We conclude that serotonin secretion in diabetes could contribute to diabetic
complications, including cardiac hypertrophy, through enhanced ROS
production.
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