ITPA polymorphism effects on decrease of hemoglobin during sofosbuvir and ribavirin combination treatment for chronic hepatitis C

Kei Morio,Michio Imamura,Yoshiiku Kawakami,Takashi Nakahara,Yuko Nagaoki,Tomokazu Kawaoka,Masataka Tsuge,Akira Hiramatsu,Hiroshi Aikata,Clair Nelson Hayes,Grace Naswa Makokha,Hidenori Ochi,Hajime Amano,Keiko Arataki,Takashi Moriya,Hiroyuki Ito,Keiji Tsuji,Hiroshi Kohno,Koji Waki,Toru Tamura,Toshio Nakamura,Kazuaki Chayama

ITPA polymorphism effects on decrease of hemoglobin during sofosbuvir and ribavirin combination treatment for chronic hepatitis C

2017

Background Polymorphisms in the inosine triphosphatase (ITPA) gene is associated with anemia induced by peg-interferon (PEG-IFN) plus ribavirin (RBV) treatment for patients with chronic hepatitis C virus (HCV) infection. However, the effect of ITPA polymorphism on sofosbuvir plus RBV treatment is unknown.

Keywords:

Gastroenterology
ITPA
Hepatitis C virus
General surgery
Polymorphism (computer science)
Hepatitis C
Anemia
Sofosbuvir
Ribavirin
Diabetes mellitus
Medicine
Internal medicine
Virus
Hepatology
Hemoglobin

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