Central plasmid antisense administration reduces blood pressure inhibiting alpha2B adrenoceptor gene expression in spontaneously hypertensive rats in vivo.

ypertension has been character-ized as a major risk factor in manycardiovascular pathophysiologicalstates, such as arteriosclerosis, stroke, coro-nary artery disease, heart failure, peripheralarterial disease and renal failure. The sym-pathetic nervous system and its adrenergiccentral and peripheral receptors play a sig-nificant pathogenic role in the developmentand maintenance of hypertension. Althoughthe stimulation of ·