An FT-IR Approach to Investigate Changes induced in Navelbine-Treated Cells

FT-IR spectroscopy has been applied to monitor molecular structural changes induced by navelbine in the resistant J82-NVB cell line. Two different sampling methods have been used: cell smears (Le Gal et al, 1993) and cells contained in KBr discs. Infrared spectroscopy combined with high pressure had been already used to differenciate between normal and malignant cells (Rigas et al, 1992; Wong et al, 1993).