Possible association of CAG repeat polymorphism in KCNN3 encoding the potassium channel SK3 with oxaliplatin-induced neurotoxicity

Benjamin Anon,Bérenger Largeau,Alban Girault,Aurélie Chantôme,Morgane Caulet,Clémence Perray,Driffa Moussata,Christophe Vandier,Chantal Barin-Le Guellec,Thierry Lecomte

Possible association of CAG repeat polymorphism in KCNN3 encoding the potassium channel SK3 with oxaliplatin-induced neurotoxicity

2018

Benjamin Anon
Bérenger Largeau
Alban Girault
Aurélie Chantôme
Morgane Caulet
Clémence Perray
Driffa Moussata
Christophe Vandier
Chantal Barin-Le Guellec
Thierry Lecomte

Introduction Data suggest a role of the potassium channel SK3 (KCNN3 gene) in oxaliplatin-induced neurotoxicity (OIN). Length variations in the polymorphic CAG repeat of the KCNN3 gene may be associated with the risk of OIN.

Keywords:

Biochemistry
Potassium channel
Neurotoxicity
Cancer research
Oxaliplatin
SK3
Gene
Medicine
HEK 293 cells
Genotyping
Gene isoform
Pharmacology
Polymorphism (computer science)
Allele
Colorectal cancer

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