Enhancement of Hypoxia-Activated Prodrug TH-302 Activity by Chk1 Inhibition
2012
Wang et al., Knockdown of Chk1, Wee1 and Myt1 by RNA interference abrogates G2 checkpoint and induces apoptosis. Cancer Bio. & Thera. 3: 305-313, 2004. Mogan et al., Mechanism of radiosensitization by the Chk1/2 inhibitor AZD7762 involves abrogation of the G2 checkpoint and inhibition of homologous recombinational DNA repair. Cancer Res. 70: 4972-4981, 2010. Carrassa and Damia. Unleashing Chk1 in cancer therapy. Cell Cycle 10: 121-2128, 2011. Meng et al., Molecular and cellular pharmacology of the hypoxia-activated prodrug TH-302. Mol Cancer Ther 11 74
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