Strategies for optimization of short-term genotoxicity tests: The synergistic effect of NADPH and NADH on P450 function in processing pre mutagens

Moreno Paolini,E. Sapigni,Patrizia Hrelia,Sandro Grilli,Giovanna Lattanzi,M. Scotti,G.Cantelli Forti

Strategies for optimization of short-term genotoxicity tests: The synergistic effect of NADPH and NADH on P450 function in processing pre mutagens

1990

Moreno Paolini
E. Sapigni
Patrizia Hrelia
Sandro Grilli
Giovanna Lattanzi
M. Scotti
G.Cantelli Forti

The synergistic effect of NADPH and NADH on P450 functions upon pre-mutagens requiring metabolism during the incubation conditions used in the liver microsomal assay (LMA) was studied

Keywords:

Microsome
Metabolism
Molecular biology
Cytochrome P450
Genotoxicity
Saccharomyces cerevisiae
Yeast
Biochemistry
Biology
In vitro
NAD+ kinase
Enzyme
Specific activity
Ethylmorphine
Mutagenesis

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