Scientific rationale for the selection of toxicity testing methods: human health assessment. [Literature analysis]

This document is the first of a two-part literature analysis of parameters associated with the various toxicity testing methods (test animal selection, pathology requirements, etc.). Acute, subchronic, chronic, and carcinogenic testing methods are covered; a discussion of some basic experimental considerations is also included. This report was prepared for the purpose of assisting and supporting the US Environmental Protecton Agency in its efforts to develop guidelines for more efficient and economical testing procedures.