Ag-Catalyzed selective fluorination of 6-substituted 2-amionpyrazines

Abstract The fluorination of 6-substituted 2-aminopyrazines with Selectfluor in the presence of Ag 2 CO 3 is established under mild conditions. This method selectively produced the fluorinated 2-aminopyrazine derivatives in fair to high yield. The regioselectivity of this reaction strongly depends upon the substituent on the 2-aminopyrazines. The transformation of the fluorinated 2-aminopyrazine 3 h into a bioactive compound was discussed as well.