Recurrence of Low-Grade Glioma: Have the Targeted Therapies Improved for Better Outcomes?

Low-grade gliomas (LGG) in adult, despite being less aggressive than high-grade gliomas, eventually will recur. For many decades, the standard radiological imaging to treatment planning has evolved. Nowadays, clinicians are leaning toward early surgical resection followed by adjuvant chemo- and/or radiotherapy rather than waiting for the tumor to recur before the treatment commences. This will put patients at risk of unavoidable treatment-related side effects and increase of resistance to further treatment following tumor recurrence. The current chapter gives an overview of changes that have been made, together with limitations that we still encounter in managing patients with LGG in order to improve progression-free survival (PFS) and overall survival (OS).