Chronic Granulomatous Disease in Morocco: Genetic, Immunological, and Clinical Features of 12 Patients from 10 Kindreds LailaAitBaba &FatimaAilal &NaimaElHafidi &MarjorieHubeau &FabienneJabot-Hanin &

AbstractPurpose Chronic granulomatous disease (CGD) is character-izedbyan inability of phagocytes toproduce reactive oxygenspecies (ROS), which are required to kill some microorgan-isms. CGD patients are known to suffer from recurrent bac-terial and/or fungal infections from the first year of lifeonwards. From 2009 to 2013, 12 cases of CGD were diag-nosed in Morocco.We describehere these Moroccancases ofCGD.Methods We investigated the genetic, immunological andclinical features of 12 Moroccan patients with CGD from 10unrelated kindreds. Fatima Ailal and Naima Hafidi contributed equally to the study.Jacinta Bustamante, Hanane Salih Alj and Ahmed Aziz Bousfiha sharesenior coauthorship.L. A. Baba : Z. Aadam : R. Saile : H. Salih AljLaboratory of Biology and Health URAC34—Metabolic andImmunologic pathology Research Team, Faculty of Science of BenM’sik, King Hassan II University, Casablanca, MoroccoF. Ailal : J. Najib : A. A. BousfihaClinical Immunology Unit, Department of Pediatric InfectiousDiseases, Averroes University Hospital, King Hassan IIUniversity-Ain Chok, Casablanca, MoroccoN. El Hafidi