Roles of CXC chemokine ligand 5(CXCL5) in dextran sulfate sodium (DSS)-induced inflammatory bowel disease in mice

Objective To investigate the role of CXC chemokine ligand 5 (CXCL5) in the pathogenesis of dextran sulfate sodium (DSS)-induced inflammatory bowel disease (IBD). Methods A mouse model of IBD was established by giving 3% DSS in drinking water. Influences of CXCL5 knockout on mouse body weight, clinical symptoms, survival rate, pathological injury and the secretion of inflammatory cytokines were analyzed. Results CXCL5 levels in serum of mice with DSS-induced IBD were significantly higher than those of the normal control group. DSS-induced weight gain, death, pathological damages and inflammatory cytokine secretion were alleviated in mice after knocking out CXCL5. Conclusion CXCL5 might promote the secretion of inflammatory cytokines in mice with DSS-induced acute colitis and aggravate pathological damages, suggesting that CXCL5 might be a potentially important candidate target for the treatment of IBD. Key words: Inflammatory bowel disease; CXC chemokine ligand 5; Inflammatory cytokine