Structure-function analyses of the human SIX1–EYA2 complex reveal insights into metastasis and BOR syndrome
2013
SIX1–EYA form a bipartite transcription factor, essential for development, whose overexpression is linked to metastasis. The crystal structure of SIX1 bound to EYA2 reveals that the interaction is mediated by an α-helix of SIX1, and a single mutation can disrupt this association and SIX1's ability to promote EMT and metastasis.
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