Evidence for nonregulatory trehalase activity inDictyostelium discoideum
1987
An in vitro activation treatment, stimulatory to the regulatory cytoplasmic trehalase ofSaccharomyces cerevisiae, had no effect on the lysosomal trehalase ofDictyostelium discoideum. Concentrations of cAMP that produced a 19 to 22-fold increase in trehalase activity inS. cerevisiae extracts did not stimulate trehalase activity inD. discoideum extracts.. cGMP and 5′-AMP were also not effective in activating the enzyme.Dictyostelium discoideum trehalase exhibits characteristics typical of nonregulatory trehalases, in agreement with its lysosomal localization. The data are consistent with the hypothesis that changes in compartmentation regulate trehalose mobilization inD. discoideum.
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