White mulberry root-bark active ingredient Morusin derivative and application and preparation method thereof

The invention discloses a Morusin derivative and a preparation method. A Morusin total-synthesis route is adopted to achieve a structure modification scheme, in the process of Morusin total synthesis, structure modification is carried out by replacing substituent groups of a reaction substrate, and a series of Morusin derivatives are synthesized. The Morusin total-synthesis route is an important anti-tumor activity lead compound, by means of synthesis of the derivatives, a compound source is provided for anti-tumor activity screening, and the derivative has great significance in finding a novel anti-tumor activity lead compound. The method is easy to operate and implement, the raw materials are low in synthesis cost and easy to obtain, synthesizing can be carried out in various kinds of organic solvent, and the derivative has good air stability, is wide in application range, and has good compatibility with various kinds of substituent groups. The derivatives have certain tumor cell growth inhibiting activity, and can be used as anti-tumor medicine or the anti-tumor medicine lead compound.