Artificial intelligence for closed-loop ventilation therapy with hemodynamic control using the open lung concept

Purpose – The purpose of this paper is to develop an automatic control system for mechanical ventilation therapy based on the open lung concept (OLC) using artificial intelligence. In addition, mean arterial blood pressure (MAP) is stabilized by means of a decoupling controller with automated noradrenaline (NA) dosage to ensure adequate systemic perfusion during ventilation therapy for patients with acute respiratory distress syndrome (ARDS). Design/methodology/approach – The aim is to develop an automatic control system for mechanical ventilation therapy based on the OLC using artificial intelligence. In addition, MAP is stabilized by means of a decoupling controller with automated NA dosage to ensure adequate systemic perfusion during ventilation therapy for patients with ARDS. Findings – This innovative closed-loop mechanical ventilation system leads to a significant improvement in oxygenation, regulates end-tidal carbon dioxide for appropriate gas exchange and stabilizes MAP to guarantee proper system...