The protective effect and mechanism of Aornia melanocarpa Elliot anthocyanins on IBD model mice

Abstract The inflammatory bowel disease (IBD) mice model induced by dextran sulfate sodium (DSS) were used to explore the effect of Aornia melanocarpa Elliot Anthocyanin (AMA) on the IBD and its possible mechanism, providing an experimental basis for the prevention and treatment of colitis in humans and animals. The results showed that AMA could inhibit the weight loss and colon length shortening of IBD mice and reduce the disease activity index (DAI) score. Histopathological staining showed that a large number of inflammatory cells infiltrated into the mucosa and submucosa of IBD mice. Goblet cells were lost, mucosa and connective tissue were damaged. After AMA treatment, the above-mentioned inflammatory changes were significantly alleviated. AMA significantly increased the expression of PPARγ, inhibited the activation of downstream NF-κB and MAPK signaling pathways, and then inhibited the secretion of inflammatory cytokines TNF-α, IFN-γ and IL-6, ameliorate IBD symptoms. It is expected to provide a theoretical and experimental basis for the development of human and animal colitis prevention and treatment drugs.