Comparison of radioactive iodide uptake in the rat thyroid between oral and intravenous bolus administration

Objective Radioiodide is commonly used to diagnose and treat hyperthyroidism and thyroid carcinoma. However, we could not find any experimental data that strictly compared the biodistribution and thyroid uptake of radioactive iodide between the oral and intravenous (iv) routes with time. This prompted us to compare 123I biodistribution and thyroid uptake to clarify the differences between oral and iv bolus administration in rats.