Gabapentina: mecanismos de acciÓn en el ano 2003

Aims. The purpose of our study was to survey the data from the main research work published about the mechanisms ofaction ofgabapentin. Development. In addition to an unquestionable Gabaergic effect, gabapentin is the first antiepileptic that has been shown to have an effect on the α 2 δ subunit of the voltage-dependent calcium channels and on hyperpolarization-activated cationic (Ih) currents. Gabapentin also exerts an indirect effect on the voltage-dependent sodium channels, slightly inhibits glutamate and reduces the excretion of certain neurotransmitters, such as serotonin, dopamine and noradrenalin. Conclusions. Gabapentin has a number of original mechanisms of action with which to account for its effects in epilepsies and in many other clinical entities.