Time course of changes in antibodies of various avidity in murine rodents in the epizootic and epidemic processes in hantavirus infection

: The paper presents the results of studying the time course of changes in antibodies of varying avidity in murine rodents. The presence of low-avidity antibodies is shown to reflect the status of acute infection in the rodent population and their active viral shedding. A relationship is shown between the detection of low-avidity antibodies in animals in spring and autumn and the rise of endemic hemorrhagic fever (EHF) morbidity. The findings demonstrate it possible to use data on the determination of antibodies of varying avidity in the population of murine rodents for the assessment of epizootic and epidemic processes.