Intestinal Neoplasia in the ApcMin Mouse: Independence from the Microbial and Natural Killer (beige Locus) Status
1997
Abstract We have tested the hypothesis that enteric bacteria are necessary for formation of intestinal adenomas in C57BL/6- Apc Min /+mouse. Germ-free mice developed 2-fold fewer adenomas than conventional controls in the medial small intestine (7.3 versus 14.9; P Apc Min /+ mice mutated at the beige locus, which controls natural killer activity, are also unaltered in adenoma multiplicity.
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