Performance Evaluation of the Sysmex XE-2100 Hematology Analyzer

A new hematology analyzer, the XE-2100 (Sysmex, Kobe, Japan), was evaluated for performance in the core laboratory of a multiple-hospital system. Complete blood count performance was evaluated in comparison to the SE-9000 (Sysmex). Differential performance was evaluated according to the National Committee for Clinical Laboratory Standards (NCCLS) document H20-A 1. Precision, carryover, correlation, and linearity studies all showed excellent results. Stability studies showed no significant change in differential parameters for a period of 68 hours at both refrigerated and room temperatures. It appears that the stability of the automated differential on the XE-2100 now exceeds the stability of red blood cell size parameters that were stable for 36 hours when refrigerated. Results comparing the XE-2100 automated differential with the 400-cell manual differential were very good. The new nucleated red blood cell (NRBC) measurement showed excellent precision and linearity. Correlation with manually enumerated NRBCs exceeded acceptable statistical standards. The evaluation led to the conclusion that the XE-2100 is an accurate and precise high-speed analyzer. Lab Hematol. 2000;6:83-92.