ID 284 – Abnormal delta cortical sources of resting state eyes closed EEG rhythms correlate with cerebrospinal fluid (CSF) ® amyloid (A®) level in amnesic MCI subjects

Aim In the framework of IMI PharmaCog project (Grant Agreement no. 115009), this study evaluated whether abnormal cortical sources of resting state electroencephalographic (EEG) rhythms are correlated to cerebrospinal fluid (CSF) ® amyloid (A®) level in amnesic Mild Cognitive Impairment (MCI) subjects. Methods Artifact-free resting state eyes-closed EEG rhythms (19 electrodes) were recorded. Individual datasets were divided into those with high CSF A® level (81 A®-negative, CSF A ® > 550 pg / ml ) and those with low CSF A® level (46 A®-positive, CSF A ® 550 pg / ml ). Regional normalized cortical sources of EEG rhythms at frequency bands of interest were estimated by LORETA package. ANOVA compared these sources between the two MCI groups ( p Results Statistical results showed: (1) source pattern Nold  p r  = −0.26; p  = 0.003) across all MCI subjects. Conclusions These results suggest a relationship between the brain amyloid charge, as revealed by CSF A® level, and pathological delta cortical sources indicating cortical disconnection in amnesic MCI subjects. EEG delta sources could represent a promising early diagnostic marker of Alzheimer’s disease (AD).