Clinical study of splenic embolization combined with lamivudine in the treatment of hepatitis B hepatocirrhosis and hypersplenism

Objective To investigate and evaluate the clinical application value and long-term therapeutic effect of splenic embolization combined with lamivudine on hepatitis B hepatocirrhosis and hypersplenism.Methods Eighty-four cases of hepatitis B hepatocirrhosis and hypersplenism were randomly divided into three groups,combined treatment group,splenic embolization group and lamivudine group,28 cases in each group,patients in combined treatment group were given lamivudine (100 mg/d)for 18 months on the basement of splenic embolization,patients in splenic embolization group were only given splenic embolization,the way was same to combined treatment group,patients in lamivudine group were orly given lamivndine,the way was same to combined treatment group.Results The effect of combined treatment group was significantly superior to splenic embolization group and lamivudine group ( P ＜0.05).Conclusions Splenic embolization combined with lamivudine can prevent the progress of the disease,reduce the complications,keep long-term liver function stability and improve living quality. Key words: Splenic embolization; Lamivudine; Hepatitis B; Hepatocirrhosis; Hypersplenism