Удосконалення експериментальних моделей інфекційних запальних процесів різної етіології сечостатевої системи жінок

Due to the great development and independent of the cultivation of microorganisms (genetic) methods of research, the vaginal microbiome, as well as the major commensals of the urinary-genital system of the person, are now more studied. According to recent data, there are different types of local, including vaginal microbiome. Typical of the normal microbiome of European and Asian women is the so-called (Lactobacillus-), which is the dominant vaginal microbiota. However, it is known that healthy women of African American and Spanish origin in the vaginal microbiome are dominated by representatives of the genera Atopobium, Corynebacterium, Anaerococcus, Peptoniphilus, Prevotella, Gardnerella, Sneathia, Eggerthella, Mobiluncus, Finegoldia, as they may be or hetero-enzymatic fermentation with acid formation [1]. Previous studies have suggested that microbiomes with a non-dominant lactobacillary component have the ability to create and maintain healthy ecosystem functioning without the pathogenic influence of individual representatives through the formation of new functional associations of microorganisms. Considering that infectious diseases of the genitourinary system are characterized by strong individual variability and arising from the violation of the ratio between commensal and pathogenic microorganisms, the aim of our work was to develop new infectious-inflammatory experimental models.