Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma

Yuka Aoki,Masanori Nojima,Hiromu Suzuki,Hiroshi Yasui,Reo Maruyama,Eiichiro Yamamoto,Masami Ashida,Mitsuhiro Itagaki,Hideki Asaoku,Hiroshi Ikeda,Toshiaki Hayashi,Kohzoh Imai,Mitsuru Mori,Takashi Tokino,Tadao Ishida,Minoru Toyota,Yasuhisa Shinomura

Genomic vulnerability to LINE-1 hypomethylation is a potential determinant of the clinicogenetic features of multiple myeloma

2012

Yuka Aoki
Masanori Nojima
Hiromu Suzuki
Hiroshi Yasui
Reo Maruyama
Eiichiro Yamamoto
Masami Ashida
Mitsuhiro Itagaki
Hideki Asaoku
Hiroshi Ikeda
Toshiaki Hayashi
Kohzoh Imai
Mitsuru Mori
Takashi Tokino
Tadao Ishida
Minoru Toyota
Yasuhisa Shinomura

Background The aim of this study was to clarify the role of global hypomethylation of repetitive elements in determining the genetic and clinical features of multiple myeloma (MM).

Keywords:

Bioinformatics
Genetics
Human genetics
Metabolomics
Systems biology
Multiple myeloma
Proteomics
Vulnerability
Biology

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