CLINICAL EVALUATION OF KODIPAVALA CHUNNAM IN THE TREATMENT OF INFECTIVE HEPATITIS, DRUG INDUCED HEPATITIS AND ALCOHOLIC HEPATITIS

The present clinical study was carried out to validate the efficacy and safety of Siddha Herbo - mineral formulation ‘Kodipavala Chunnam’ in the treatment of Infective hepatitis, Drug induced hepatitis and Alcoholic hepatitis. Open clinica l trial was conducted in 40 patients with these three categories of hepatitis in Arignar Anna Govt.Hospital of Indian Medicine and Homeopathy, Chennai. The trial drug Kodipavala Chunnam was administered in all the patients at the dose of 100 mg to 200 mg t hrice a day with honey depending on severity. The clinical improvement shown by cases treated with Kodipavala Chunnam was more quick and significant. Before drug administration to patients it was observed that a significant increase in the levels of serum bilirubin ALT, AST, SAP, GGT and globulin. Elevated levels of these parameters are indicative of functional impairment of liver . Administration of KPC remarkably ( P<0.001 ) restored elevated serum bilirubin ALT, AST, SAP, GGT and globulin towards normal val ue. Overall results revealed that out of 40 patients 10 patients had excellent relief, 26 had good relief, 3 cases showed satisfactory result and only one case showed fair response. The results clearly ha ve shown that the Kodipavala Chunnam treatment to th e jaundice therapy helped in cutting down the course of the disease and relieving jaundice earlier. There were no new or unex pected safety events noticed during the course of the treatment. Keyword s : Hepatitis, hyperbilirubinaemia, jaundice, Kodipavala Chu nnam, Liver dysfunction, Siddha Medicine.