Terpendoles, novel ACAT inhibitors produced by Albophoma yamanashiensis. III. Production, isolation and structure elucidation of new components.

Eight new components of terpendoles E to L were isolated and characterized from the culture broth of Albophoma yamanashiensis using a different production medium. All the structures were elucidated by spectroscopic analyses including various NMR experiments, indicating that all the terpendoles have the same indoloditerpene core as terpendoles A to D. Terpendoles J, K and L showed the moderate inhibition against acyl-CoA : cholesterol acyltransferase (ACAT) activity with IC 50 values of 38.8, 38.0 and 32.4 μM in rat liver microsomes, respectively. But terpendoles E∼I showed weak activities (IC 50 145∼388 μM).