Effect of Physalis and Choline on Lipid Profile and Antioxidant Activity in Hepatic Toxicity Rats

Forty male Sprague-Dawley rats weighing 120+6g were divided into five groups. The first group kept as normal control (-ve) group (n= 8 rats) which fed on basal diet only. The rest of rats were administered paracetamol drug at a single dose of 2 g/kg by stomach tube to induce liver injury then classified into four groups. One of them acted as control (+ve) and the other three treated groups were physalis extract (600 mg/kg b. w), choline (1000 mg/kg bw) and physalis extract with choline (600 mg/kg b. w+1000 mg/kg bw). Results showed that rats fed diet contains physalis extract or choline or physalis extract with choline showed a significant increase in body weight gain, food intake and FER, and also serum total protein and high density lipoprotein cholesterol (HDLc). Moreover, they had a significant increase in liver glutathione S-transferase, superoxide dismutase, catalase, glutathione peroxidase and glycogen compared to rats of control (+ve) group. On the other side, they showed a significant decrease in aspartate and alanine amino transferase, alkaline phosphatase & gamma glutamyle transferase enzymes, total bilirubin and cholesterol (CHO) in serum. Also, they showed a significant decrease in CHO/HDLc ratio and also, malondialdehyde, cholesterol and total lipids in liver compared to rats of control (+ve) group. Rat group which fed physalis extract with choline in diet showed improvement of nutritional results, liver function parameter, lipid profile and also antioxidant activity.