Experimental research on fibrin clot permeability with albumin present

Fibrin clots are characterized by low permeability, which affects the spatial aspects of the coagulation process. Between blood plasma albumins noncovalent interactions are possible. The hypothesis that albumin accumulates in clots was examined. It was shown that albumin can not bind with fibrin clots in noticeable quantities, i.e., its presence has no impact on clot permeability neither during formation nor after-wards. During filtration at the free clot boundary a hardening zone resembling compacted clots in its permeability is formed.