Effects of the KI-180 and KI-188 Calcium Formulae on the Growth and Development of Rats

Department of Food Science and Biotechnology, Kangwon National UniversityAbstract Herbs have active components that promote the growth rate of both animals and human. The KI-180 and KI-188 calcium food formulae contain Acanthopanacis cortex, Bombysis corpus and hoelen, seaweed calcium, chlorellaextract, spirulina, colostrum powder, and other natural and functional components. We evaluated the growth-promotingeffects of these formulae by analyzing the weight, femur and backbone, alkaline phosphatase, osteocalcin, testosterone,insulin-like growth factor (IGF)-1, and IGF binding protein-3 (IGFBP-3) of growing rats. Growing rats administered withKI-180 and KI-188 calcium showed the increase of body weight, body length, and femur weight and length of growingrats. In addition, administration of KI-180 and KI-188 calcium increased the alkaline phosphatase activity, the levels ofosteocalcin and the growth hormones IGF-1 and IGFBP-3 of growing rats. The impact of KI-180 and KI-188 calcium onthe physical development of growing rats suggests that the incorporation of these food formulae in the diets of growingchildren may promote the physical development.Keywords: KI-180, growth hormone, IGF-1, IGFBP-3