O-092a Left Ventricular Function In Children With Acute Leukaemia Receiving Hematopoietic Stem Cell Transplantation

Hematopoietic stem cell transplantation (HSCT) is a curable therapy for paediatric cancer. Cardiovascular complications are the leading cause of late morbidity and mortality in long-term childhood cancer survivors. However, cardiac function in children after HSCT is not well known. We assessed left-ventricular (LV) function in children after HSCT for acute leukaemia by using tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE). Forty consecutive patients (median 11.9 years) who had HSCT for acute leukaemia between 2011 and 2014 had undergone an echocardiographic assessment before and after (median 9.2 month) HSCT. LV function parameters, including conventional, TDI, and STE data, were collected from patients’ echocardiographic data, and were compared with those of controls (n = 39, median age 9 years). All patients had anthracycline as a pre-HSCT chemotherapy. At post-HSCT, patients had decreased LV ejection fraction (p = 0.06), rate-corrected velocity of fibre shortening (p = 0.04), and mitral septal annular E’ velocity (p = 0.03) compared with controls. STE parameters also decreased in patients; mid LV global circumferential strain (p 400 mg/m 2 showed significantly lower mid LV global circumferential strain (p