Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle

Hirofumi Misu,Hiroaki Takayama,Yoshiro Saito,Yuichiro Mita,Akihiro Kikuchi,Kiyoaki Ishii,Keita Chikamoto,Takehiro Kanamori,Natsumi Tajima,Fei Lan,Yumie Takeshita,Masao Honda,Mutsumi Tanaka,Seiji Kato,Naoto Matsuyama,Yuya Yoshioka,Kaito Iwayama,Kumpei Tokuyama,Nobuhiko Akazawa,Seiji Maeda,Kazuhiro Takekoshi,Seiichi Matsugo,Noriko Noguchi,Shuichi Kaneko,Toshinari Takamura

Deficiency of the hepatokine selenoprotein P increases responsiveness to exercise in mice through upregulation of reactive oxygen species and AMP-activated protein kinase in muscle

2017

Selenoprotein P is released from the liver and acts through LRP1 in the muscle to contribute to exercise resistance in mouse and man by inhibiting ROS levels via inhibition of AMPK and PGC-1α.

Keywords:

AMP-activated protein kinase
Type 2 diabetes
Selenoprotein P
LRP1
Endocrinology
Downregulation and upregulation
AMPK
Reactive oxygen species
Biology
Diabetes mellitus
Internal medicine

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