MYOCARDIAL ISCHEMIA AND INFARCTION NON-INVASIVE IMAGING OF THE LOCALIZATION AND TIME COURSE OF CELL DEATH IN A CANINE MODEL OF ACUTE MYOCARDIAL INFARCTION AND REPERFUSION: DEMONSTRATION OF EARLY AND LATE PHASES OF REPERFUSION CELL DEATH

Methods: The left anterior descending artery (LAD) was occluded using a 3 mm PTCA balloon catheter (n = 12). A constant gadolinium (Gd) infusion was administered during MRI to assess MI. Regional myocardial signal enhancement and function were recorded every 10 min during 90 min of ischemia followed by 120 min of R, and again at 24 and 48 hr post R. A catheter was inserted into the coronary sinus to measure creatine kinase (CK) leak across the coronary circulation.