Serum Homocystein Level In COPD Patients: Possible Beneficial Effect Of Antioxidants

Chronic obstructive pulmonary disease (COPD) has a dramatic effect on quality of life. Elevated level of homocystein (HCY) i n C OPD are risk factors for cardiovascular diseases. Objective: This study was to evaluate the level of HCY and the role of antioxidant supplementation in COPD patients. Methods: Homocysteine and folic a cid ha ve been determined by HPLC while, the other parameters have been determined by sp ectrophotometer. R esults: Our stu dy re vealed that P araoxonase and arylesterase activity of Paraoxonase-1 (PON-1), as a hi gh de nsity lipoprotein bo und enzyme and its major r ole i s to prevent oxidation of low density lipoprotein, were reduced in the serum of acute and stable COPD patients. HCY 12 level has been elevated in acut e and stable C OPD as compared with norm al healthy control. Vitamin B 12) (Vit B only decreased in acute COPD while Folic acid level has not a significant change. 12 Supplementation of an tioxidant co mbination ameliorated the level o f H CY (acute and stable) a nd Vit B in acut e C OPD patients. Conclusion: we concluded that HCY may be el evated as a res ult of oxidative inflammatory response and co supplementation of antioxidant combination co uld be of important value in m inimizing the risk of hig h HCY level, especially in a cute COPD patients.