DIABETES MELLITUS IS ASSOCIATED WITH IMPAIRED MITOCHONDRIAL OXIDATIVE PHOSPHORYLATION SYSTEM AND INCREASED OXIDATIVE STRESS IN HUMAN ATRIA

The diabetic heart exhibits a reduced tolerance to metabolic stress resulting in higher susceptibility to injury and heart failure yet the underlying mechnisms of reduced tolerance are not fully defined. We hypothesized that impairment in oxidative phosphorylation (OXPHOS) and increased oxidative