Atrophy of rabbit testes associated with production of antiserum to bovine luteinizing hormone.

SummaryInjections of purified bovine LH (NIH-LH-B3) in rabbits produced circulating antibodies which were associated with atrophy of the testes and epididymides. Bovine LH and crude rabbit anterior pituitary extract contained a similar antigen which was not a component of normal bovine serum. Results were attributed to an autoimmune phenomenon with circulating antibodies common to NIH-LH-B3 and endogenous gonadotropin.