Preparation of nanostructured lipid carriers (NLC) method and products made
2011
A method of preparing nanostructured lipid carriers or nanoemulsion, comprising the steps of: a solid lipid, lipid, or oil phase liquid lipophilic surfactant in combination with liquefaction, the liquefied higher than the melting point of the oil phase at a temperature to prevent the oil phase of the recrystallization; liquefied in the oil phase was added the active ingredient, then mixed into the oil phase containing the hydrophilic surfactant aqueous phase to form a mixture, wherein the oil phase in water when mixed, the water phase was preheated to the oil phase to avoid recrystallization temperature; pre-emulsion is formed from the mixture; preemulsion homogenized for providing nanostructured lipid carriers, and homogenized during rheology modifier; characterized in that the preemulsion of and / or nanostructured lipid carriers formed is cooled.
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