Use of Intravenous immune globulin in Critically Ill Patients

Intravenous immune globulin (IVIG) preparations have been suggested for many years for the treatment of various conditions. It is apparent, through in vitro and in vivo studies, that IVIG exerts potent anti-inflammatory and immunomodulatory effects. However, the mechanism of action remains mostly unknown. The following article reviews the current literature and summarizes what is known about the mechanism of action of IVIG and the use of IVIG to treat certain conditions. Specifically, the use of IVIG for treatment of critically ill patients is outlined.