Analysis of Clinical and Laboratory Features of IgE Multiple Myeloma

Objective: The clinical and laboratory features of an IgE multiple myeloma were analyzed. Methods: A 52-year-old woman admitted with progressive lumbago and weakness was reported and with literatures review. X rays and bone scan of this patient showed multiple compression fractures at T_(8)、T_(11)、T_(12)、L_(1 )and osteoporosis of pelvis and all vertebrae. With the exception of hypersedimentation rate, mild decreased hemoglobin, mild hypercalcemia and elevated blood urea, routine biochemistry values were within reference limits. Plasma cell was not observed in the peripheral blood. Results: Serum protein electrophoresis showed a monoclonal protein in the gammaglobulin fraction. Immuofixation confirmed the presence of an IgE kappa monoclonal protein. A bone marrow smear revealed abnormal plasma cells account for 72.8%of nucleated cells. Bence-Johns protein was detected in the urine. The diagnosis of IgE-κ multiple myeloma was established for this patient from the clinical, laboratory and radiological data. Conclusion: The findings for this patient were compared with the previous reports of IgE myeloma. It was concluded that IgE multiple myeloma exhibited some special clinical and laboratory features.