Alterations in Myocardial-Specific Creatine Phosphokinase in Children with Severe Reactive Airway Disease Treated with Intravenous Isoproterenol

Objective To describe the pattern of alterations in creatine phosphokinase (CPK) and creatine phosphokinase-myocardial isoenzyme (CPK-mb) levels and electrocardiogram (ECG) changes in children treated with intravenous infusion of isoproterenol, as determined by elevation of CPK-mb levels/indices and/or ischemic ECG changes. Design Prospective observational study. Setting A pediatric intensive care unit of a university teaching hospital. Subjects Twenty-two critically ill children (age: 3 months—17 years) with severe reactive airway disease who required intravenous isoproterenol. Interventions None. Measurements and Main Results Twenty-two children with severe reactive airway disease [pH 7.25 (7.01-7.54), Paco2 55 (23-113), and Pao2 92 (54-361)] were enrolled in the study. Baseline ECGs prior to intravenous isoproterenol were unremarkable. Baseline CPK-mb levels/indices were found to be abnormally elevated in 5 children prior to intravenous isoproterenol. Four of these children manifested a decrease in CPK...