Organocatalytic anti-Mannich Reactions with Dihydroxyacetone and Acyclic Dihydroxyacetone Derivatives: A Facile Route to Amino Sugars

The first primary amine-containing amino acid-catalyzed anti-Mannich reactions of dihydroxyacetone and acyclic dihydroxyacetone derivatives with a variety of imines have been developed. This approach complements proline-based strategies in the preparation of amino sugars.